The aoColumnDefs’ aTargets parameter lets you give indexes offset from the right (use a negative number) as well as from the left. So you could do:
aoColumnDefs: [
{
bSortable: false,
aTargets: [ -1 ]
}
]
The equivalent new API (for DataTables 1.10+) would be:
columnDefs: [
{ orderable: false, targets: -1 }
]