You didn’t specify if the order matters. If it does not, you can do this in >= Python 2.7:
l1 = ['a', 'b', 'c', 'b', 'c']
l2 = ['a', 'b', 'c', 'b']
from collections import Counter
c1 = Counter(l1)
c2 = Counter(l2)
diff = c1-c2
print list(diff.elements())