The factory method has an fallback when it fails to create the culture info.
So if you use a specific culture like ‘en-XX’, the culture info instance can’t be created, an exception will throw and a retry with the neutral culture ‘en’ will succeed.
Below the source of the factory method
public static CultureInfo CreateSpecificCulture(string name)
{
CultureInfo info;
try
{
info = new CultureInfo(name);
}
catch (ArgumentException)
{
info = null;
for (int i = 0; i < name.Length; i++)
{
if ('-' == name[i])
{
try
{
info = new CultureInfo(name.Substring(0, i));
break;
}
catch (ArgumentException)
{
throw;
}
}
}
if (info == null)
{
throw;
}
}
if (!info.IsNeutralCulture)
{
return info;
}
return new CultureInfo(info.m_cultureData.SSPECIFICCULTURE);
}
So the I prefer the factory method.