Determining when a column value changes in pandas dataframe

You can create a new column for the difference

> df['C'] = df['B'].diff()
> print df
   #  A  B   C
0  1  2  3 NaN
1  2  3  3   0
2  3  4  4   1
3  4  5  4   0
4  5  5  4   0

> df_filtered = df[df['C'] != 0]
> print df_filtered
   #  A  B  C
2  3  4  4  1

This will your required rows