Conditional required validation in angular reactive form

For me it worked perfectly like this:

this.userCustomForm.get('age').valueChanges.subscribe(val => {
  if (condition) {
    this.userCustomForm.controls['licenseNo'].setValidators([Validators.required]);
  } else {
    this.userCustomForm.controls['licenseNo'].clearValidators();
  }
  this.userCustomForm.controls['licenseNo'].updateValueAndValidity();
});

You have to updateValueAndValidity of the form for the changes to take effect.