update
Updating with what i think is the most valid approach nowadays.
You can use a Unicode property escapes Regular expression if the support suits you. In this case you can use the General category property for Uppercase Letter Lu.
function isUppercase(word){
return /^\p{Lu}/u.test( word );
}
older answers
var word = "Someword";
console.log( word[0] === word[0].toUpperCase() );
or
var word = "Someword";
console.log( /[A-Z]/.test( word[0]) );
or
var word = "Someword";
console.log( /^[A-Z]/.test( word) );
See toUpperCase() and test()