Changing the active class of a link with the twitter bootstrap css in python/flask

Have you looked at this ? https://jinja.palletsprojects.com/en/3.0.x/tricks/#highlighting-active-menu-items

Highlighting Active Menu Items

Often you want to have a navigation bar with an active navigation item. This is really simple to achieve. Because assignments outside of blocks in child templates are global and executed before the layout template is evaluated it’s possible to define the active menu item in the child template:

{% extends "layout.html" %}
{% set active_page = "index" %}

The layout template can then access active_page. Additionally it makes sense to define a default for that variable:

{% set navigation_bar = [
    ("https://stackoverflow.com/", 'index', 'Index'),
    ('/downloads/', 'downloads', 'Downloads'),
    ('/about/', 'about', 'About')
] -%}

{% set active_page = active_page|default('index') -%}
...
<ul id="navigation">
    {% for href, id, caption in navigation_bar %}
    <li{% if id == active_page %} class="active"{% endif
    %}><a href="{{ href|e }}">{{ caption|e }}</a>
    </li>
{% endfor %}
</ul>