Sure you can!

Django itself arent asyncronous so you have to use a Socket.IO server in parallel with your normal django server, node.js isnt always a good choice but there exists others written in pure python.

here is a blog/tutorial that uses gevent as socket.io server.

http://codysoyland.com/2011/feb/6/evented-django-part-one-socketio-and-gevent/

For a similar solution that has a bit more history you can look at Orbited, (www.orbited.org)