Yes it’s absolutely possible. Blazor does not have a monopoly on C#/WASM and it’s far from clear that it’s going to wind up being the best long term option (and a lot of evidence it’s not).
I recommend starting with the Uno WASM Bootstrap. https://github.com/unoplatform/Uno.Wasm.Bootstrap
2022-06-30 Edit –
More evidence Blazor is not the only game in town nor even at the forefront of innovation here:
https://visualstudiomagazine.com/articles/2022/06/29/uno-platform-4-4.aspx