The other posts have given good advice, but I thought it might be nice to show an example of where it definitely makes a difference:
using System;
using System.Globalization;
using System.Threading;
class Test
{
static void Main()
{
CultureInfo turkish = CultureInfo.CreateSpecificCulture("tr");
Thread.CurrentThread.CurrentCulture = turkish;
// In Turkey, "i" does odd things
string lower = "i";
string upper = "I";
// Prints False
Console.WriteLine(lower.Equals(upper,
StringComparison.CurrentCultureIgnoreCase));
// Prints True
Console.WriteLine(lower.Equals(upper,
StringComparison.InvariantCultureIgnoreCase));
}
}
(There are no doubt many other cases – this was just the first one I thought of.)