UPDATE 2
There has been an improvement in user flow of this feature in latest versions of chrome. Please refer to https://developer.chrome.com/devtools/docs/blackboxing
UPDATE 1
Since Chrome version 38, you no longer have to enable Developer Tools experiments.
Below details are only for history
This is possible now in chrome version 30+.
- Enable “Enable Developer Tools experiments” from
chrome://flags/#enable-devtools-experiments. (Yes, you need to type that where you type the URL) - Relaunch chrome
- Click on settings icon in Chrome Developer Tools
- Go to Experiments section. Notice the WARNING 😉 and then tick
Enable frameworks debugging support. (You also might want to tryShow step-in candidates while debugging) - Now, close Chrome Dev Tools and again open it.
- Click on settings icon in Chrome Developer Tools
- In general section you will find “Skip stepping through sources with particular names”. Tick that and provide regex for the javascript file names which you want to skip stepping into.

Source: Tips and Tricks: Ignoring library code while debugging in Chrome