The solution above is fine if you don’t need to specify the filename, but we wanted to keep the filename default specified for the user.
Our solution ended up being the filename itself as it contained some commas. I did a replace on the commas with “” and the file now delivers the document as expected in Chrome.
FileName = FileName.Replace(",", "")
Response.ContentType = "application/pdf"
Response.AddHeader("content-disposition", "attachment; filename=" & FileName)
Response.BinaryWrite(myPDF)