Pros

Using well-defined types makes the code far easier and safer to port, as you won’t get any surprises when for example one machine interprets int as 16-bit and another as 32-bit. With stdint.h, what you type is what you get.

Using int etc also makes it hard to detect dangerous type promotions.

Another advantage is that by using int8_t instead of char, you know that you always get a signed 8 bit variable. char can be signed or unsigned, it is implementation-defined behavior and varies between compilers. Therefore, the default char is plain dangerous to use in code that should be portable.

If you want to give the compiler hints of that a variable should be optimized, you can use the uint_fastx_t which tells the compiler to use the fastest possible integer type, at least as large as ‘x’. Most of the time this doesn’t matter, the compiler is smart enough to make optimizations on type sizes no matter what you have typed in. Between sequence points, the compiler can implicitly change the type to another one than specified, as long as it doesn’t affect the result.

Cons

None.

Reference: MISRA-C:2004 rule 6.3.”typedefs that indicate size and signedness shall be used in place of the basic types”.

EDIT : Removed incorrect example.