Good news, everyone!
I just released cairocffi:
http://packages.python.org/cairocffi/
It’s a replacement for pycairo that installs with pip in a virtualenv, runs on Python 2 and 3, as well as PyPy.
pip install cairocffi
In your code:
import cairocffi as cairo
# Enjoy the same API as Pycairo.
Feedback welcome. (Although the issue tracker might be a better channel than here.)