Deserialize JSON to 2 different models

First off, your models are slightly incorrect. The name properties need to be strings, instead of integers:

class Guardian
{

    [JsonProperty(PropertyName = "guardian_id")]
    public int ID { get; set; }

    [JsonProperty(PropertyName = "guardian_name")]
    public string Name { get; set; }            // <-- This
}


class Patient
{

    [JsonProperty(PropertyName = "patient_id")]
    public int ID { get; set; }

    [JsonProperty(PropertyName = "patient_name")]
    public string Name { get; set; }            // <-- This
}

Once you’ve corrected that, you can deserialize the JSON string into two lists of different types. In your case, List<Guardian> and List<Patient> respectively:

string json = @"[{'guardian_id':'1453','guardian_name':'Foo Bar','patient_id':'938','patient_name':'Foo Bar'}]";
var guardians = JsonConvert.DeserializeObject<List<Guardian>>(json);
var patients = JsonConvert.DeserializeObject<List<Patient>>(json);