There is a difference, and it has to do with whether that list is referenced from multiple places/names.
>>> a = [1, 2, 3]
>>> b = a
>>> del a[:]
>>> print(b)
[]
>>> a = [1, 2, 3]
>>> b = a
>>> a = []
>>> print(b)
[1, 2, 3]
Using del a[:]
clears the existing list, which means anywhere it’s referenced will become an empty list.
Using a = []
sets a
to point to a new empty list, which means that other places the original list is referenced will remain non-empty.
The key to understanding here is to realize that when you assign something to a variable, it just makes that name point to a thing. Things can have multiple names, and changing what a name points to doesn’t change the thing itself.