On Linux, you can use posix_spawn(2) with the POSIX_SPAWN_USEVFORK flag to avoid the overhead of copying page tables when forking from a large process.
See Minimizing Memory Usage for Creating Application Subprocesses for a good summary of posix_spawn(2), its advantages and some examples.
To take advantage of vfork(2), make sure you #define _GNU_SOURCE before #include <spawn.h> and then simply posix_spawnattr_setflags(&attr, POSIX_SPAWN_USEVFORK)
I can confirm that this works on Debian Lenny, and provides a massive speed-up when forking from a large process.
benchmarking the various spawns over 1000 runs at 100M RSS
user system total real
fspawn (fork/exec): 0.100000 15.460000 40.570000 ( 41.366389)
pspawn (posix_spawn): 0.010000 0.010000 0.540000 ( 0.970577)