Is there a way to match inequalities in Python ≥ 3.10?

You can use guards:

match a:
    case _ if a < 42:
        print('Less')
    case _ if a == 42:
        print('The answer')
    case _ if a > 42:
        print('Greater')

Another option, without guards, using pure pattern matching:

match [a < 42, a == 42]:
    case [True, False]:
        print('Less')
    case [_, True]:
        print('The answer')
    case [False, False]:
        print('Greater')