Reading input sound signal using Python

Have you tried pyaudio?
To install:

python -m pip install pyaudio

Recording example, from the official website:

PyAudio example: Record a few seconds of audio and save it to a WAVE file.

import pyaudio
import wave

CHUNK = 1024
FORMAT = pyaudio.paInt16
CHANNELS = 2
RATE = 44100
RECORD_SECONDS = 5
WAVE_OUTPUT_FILENAME = "output.wav"

p = pyaudio.PyAudio()

stream = p.open(format=FORMAT,
                channels=CHANNELS,
                rate=RATE,
                input=True,
                frames_per_buffer=CHUNK)

print("* recording")

frames = []

for i in range(0, int(RATE / CHUNK * RECORD_SECONDS)):
    data = stream.read(CHUNK)
    frames.append(data)

print("* done recording")

stream.stop_stream()
stream.close()
p.terminate()

wf = wave.open(WAVE_OUTPUT_FILENAME, 'wb')
wf.setnchannels(CHANNELS)
wf.setsampwidth(p.get_sample_size(FORMAT))
wf.setframerate(RATE)
wf.writeframes(b''.join(frames))
wf.close()

This example works on my laptop with Python 2.7.11 (and 3.5.1) in Windows 8.1, pyaudio 0.2.9.