I was facing the same problem for a mat-option inside a mat-select and fixed this way:
Template
<mat-select>
<mat-option (onSelectionChange)="handleMetaSignalChange(metaSignal.name,$event);" *ngFor="let metaSignal of metaSignals" [value]="metaSignal">
{{ metaSignal.name }}
</mat-option>
</mat-select>
Code
handleMetaSignalChange(metaSignal: string, event: any) {
if (event.isUserInput) { // ignore on deselection of the previous option
console.log('Meta Signal Changed to ' + metaSignal + event.isUserInput);
}
}