In a .md file html code can be put. A very easy mode to get this effect is doing a table without borders,
<table border="0">
<tr>
<td><b style="font-size:30px">Title</b></td>
<td><b style="font-size:30px">Title 2</b></td>
</tr>
<tr>
<td>Lorem ipsum ...</td>
<td>Lorem ipsum ...</td>
</tr>
</table>