Query using multiple conditions

Check out this answer to the same question. It is more detailed than the answer I give here. The keypath parameter to store.createIndex and IDBKeyRange methods can be an array. So, crude example:

// In onupgradeneeded
var store = db.createObjectStore('mystore');
store.createIndex('myindex', ['prop1','prop2'], {unique:false});

// In your query section
var transaction = db.transaction('mystore','readonly');
var store = transaction.objectStore('mystore');
var index = store.index('myindex');
// Select only those records where prop1=value1 and prop2=value2
var request = index.openCursor(IDBKeyRange.only([value1, value2]));
// Select the first matching record
var request = index.get(IDBKeyRange.only([value1, value2]));