var mystring = "hello world test world";
var find = "world";
var regex = new RegExp(find, "g");
alert(mystring.replace(regex, "yay")); // alerts "hello yay test yay"
In case you need this into a function
replaceGlobally(original, searchTxt, replaceTxt) {
const regex = new RegExp(searchTxt, 'g');
return original.replace(regex, replaceTxt) ;
}