Starting with CLion 1.5 144.3143 (2016-01-20), you can clear the cmake cache without loosing the CLion indexes and without restarting (meaning: very fast, also on huge projects):
Tool | CMake | "Reset cache and reload project".
If that for some reasons is not enough, or if you have an older CLion, you can do the more radical:
File | "Invalidate Caches / Restart"
and click on “Invalidate and restart”.
EDITS
- 2016-01-20: add the faster method available with newer CLion.