As of at least version 1.5.79, botocore accepts a proxies
argument in the botocore config.
e.g.
import boto3
from botocore.config import Config
boto3.resource('s3', config=Config(proxies={'https': 'foo.bar:3128'}))
boto3 resource
https://boto3.readthedocs.io/en/latest/reference/core/session.html#boto3.session.Session.resource
botocore config
https://botocore.readthedocs.io/en/stable/reference/config.html#botocore.config.Config