Try with
c:\WINDOWS\Microsoft.NET\Framework\v4.0.30319\aspnet_regiis.exe -iru
When multiple versions of the .NET Framework are executing side-by-side on a single computer, the ASP.NET ISAPI version mapped to an ASP.NET application determines which version of the common language runtime (CLR) is used for the application.
Above command will Installs the version of ASP.NET that is associated with Aspnet_regiis.exe and only registers ASP.NET in IIS.
https://support.microsoft.com/en-us/help/2015129/error-message-after-you-install-the–net-framework-4-0-could-not-load