Angular uses webpack and all type script files are listed under it. To select your target typescript file, Chrome’s Developer tool (F12). Go to Source tab,
Select Chrome “webpack://”->”src/app” -> your typescript file.
Or in older version of chrome follow this path “webpack://”->”.”->”src/app” -> your typescript file ( See the image file).
Or Ctrl+P to locate your file(as suggested by fergal_dd)
Then set the debug line marker on ts file and use normal java script keyboard(F8, F10, F11 etc) feature to debug it.