I stumbled upon this question but decided to run the queries manually through a Bash script:
#!/bin/bash
# Make sure that NOBODY can access the server without a password
mysql -e "UPDATE mysql.user SET Password = PASSWORD('CHANGEME') WHERE User="root""
# Kill the anonymous users
mysql -e "DROP USER ''@'localhost'"
# Because our hostname varies we'll use some Bash magic here.
mysql -e "DROP USER ''@'$(hostname)'"
# Kill off the demo database
mysql -e "DROP DATABASE test"
# Make our changes take effect
mysql -e "FLUSH PRIVILEGES"
# Any subsequent tries to run queries this way will get access denied because lack of usr/pwd param