span {
cursor:pointer;
color:blue;
text-decoration:underline;
}
<a href="#">Hyperlink</a><br />
<span>Span</span>
Additionally, you can use :hover pseudo-class to style the element when hovered (you can use any styles not just the ones originally used). For example:
span:hover {
text-decoration:none;
text-shadow: 1px 1px 1px #555;
}