JavaScript: Object Rename Key

The most complete (and correct) way of doing this would be, I believe:

if (old_key !== new_key) {
    Object.defineProperty(o, new_key,
        Object.getOwnPropertyDescriptor(o, old_key));
    delete o[old_key];
}

This method ensures that the renamed property behaves identically to the original one.

Also, it seems to me that the possibility to wrap this into a function/method and put it into Object.prototype is irrelevant regarding your question.