There is both window.onbeforeunload and window.onunload, which are used differently depending on the browser. You can assign them either by setting the window properties to functions, or using the .addEventListener:
window.onbeforeunload = function(){
// Do something
}
// OR
window.addEventListener("beforeunload", function(e){
// Do something
}, false);
Usually, onbeforeunload is used if you need to stop the user from leaving the page (ex. the user is working on some unsaved data, so he/she should save before leaving). onunload isn’t supported by Opera, as far as I know, but you could always set both.