To add, you’d need:
https://alembic.sqlalchemy.org/en/latest/ops.html#alembic.operations.Operations.create_unique_constraint
from alembic import op
op.create_unique_constraint('uq_user_name', 'user', ['name'], schema="my_schema")
To drop, you’d need:
https://alembic.sqlalchemy.org/en/latest/ops.html#alembic.operations.Operations.drop_constraint
op.drop_constraint('uq_user_name', 'user', schema="my_schema")