Without knowing your database it’s tough to be specific. In SQL Server the syntax would be something like …
UPDATE MyTable
SET
Field1 = IsNull(@Field1, Field1),
Field2 = IsNull(@Field2, Field2),
Field3 = IsNull(@Field3, Field3)
WHERE
<your criteria here>
EDIT
Since you specified SQLLite …replace my IsNull function with COALESCE() or alternately look at the IfNull function.