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Library support. Not all libraries are compatible with PyPy.
Your best bet is to actually try running
pypy manage.py test
and see if it breaks. Then you know which dependencies need to be brought into line.http://reinout.vanrees.org/weblog/2011/06/06/django-and-pypy.html
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Webservers
You can’t use pypy with Apache. You need to use a pure-python webserver + nginx.
You MAY get it working on uwsgi.