How to know if JavaScript string.replace() did anything?

A simple option is to check for matches before you replace:

var regex = /i/g;
var newStr = str;

var replaced = str.search(regex) >= 0;
if(replaced){
    newStr = newStr.replace(regex, '!');
}

If you don’t want that either, you can abuse the replace callback to achieve that in a single pass:

var replaced = false;
var newStr = str.replace(/i/g, function(token){replaced = true; return '!';});