You need to spy on a property of rxjs. Using spyOnProperty will solve the error. Try this
import * as rxjs from 'rxjs'
import { of, fromEvent } from 'rxjs';
spyOnProperty(rxjs, 'fromEvent').and.returnValue(of({}))
you can also add to getter/setters using this like
spyOnProperty(rxjs, 'fromEvent', 'get').and.returnValue(false)
Hope this helps