How can I obtain an ‘unbalanced’ grid of ggplots?

grid.arrange draws directly on the device; if you want to combine it with other grid objects you need arrangeGrob, as in

 p = rectGrob()
 grid.arrange(p, arrangeGrob(p,p,p, heights=c(3/4, 1/4, 1/4), ncol=1),
              ncol=2)

Edit (07/2015): with v>2.0.0 you can use the layout_matrix argument,

 grid.arrange(p,p,p,p, layout_matrix = cbind(c(1,1,1), c(2,3,4)))

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